The launch of OpenAI's ChatGPT in late 2022 spurred a tidal wave of interest in generative artificial intelligence (AI) companies, sending many of their stock prices parabolic. Palantir Technologies (NASDAQ: PLTR) and Arm Holdings (NASDAQ: ARM) were major beneficiaries.

Duquesne Family Office's chief is cashing in his chips on two leading artificial intelligence (AI) stocks in favor of a drugmaker whose shares are up by 112% for the year.

Based on stock price targets, the most bullish analyst on Palantir’s stock could be considered by some to actually be bearish.

Palantir Technologies (NASDAQ: PLTR) stock has been on a tearing run on the market in 2024, logging remarkable gains of 370% as of this writing. The rapid uptake of artificial intelligence (AI) software solutions by organizations and governments played a central role in this terrific surge.

As you can see, the company's price-to-sales ratio has nearly quadrupled over the last year. The P/S ratio isn't a perfect measure of valuation, but 67.5 is off-the-charts high. A P/S of 20 is typically considered expensive, even in an industry like software where stocks tend to earn high valuations.

Palantir Technologies (NASDAQ:PLTR) has experienced a remarkable surge in its valuation this year, with the company’s stock price rocketing more than 330% year-to-date at the time of writing. This incredible upside has been driven by improving growth expectations for companies like Palantir focused on developing its artificial intelligence platform and expanding its customer base.

The Dow Jones dropped Thursday on surprise weekly jobless claims. Nvidia stock hit a new buy point Tuesday. Forecasters see good chances the U.S. economy will continue to grow steadily in 2025, while the odds of a downturn have diminished in recent months.

With its stock up 2,500% in the past five years, it's perhaps not surprising that investors are looking for the next Nvidia (NASDAQ: NVDA). The company has been the biggest winner from the artificial intelligence (AI) boom and as a result has become one of the largest companies in the world.

Palantir Technologies stock (NASDAQ: PLTR) remains up by over 4x since the beginning of the year, trading at about $74 per share.

There's no way to deny it: 2024 was a stunning year for the stock market. As of this writing, the S&P 500 is up nearly 28% year to date. As always, there are stocks significantly outperforming this otherwise impressive return.

Palantir's stock has surged without any selling pauses, raising concerns about a potential sharp pullback. Explore more details here.

The stock was by far the S&P 500 index's SPX best performer this year, as it has skyrocketed 380.9% year to date to boost Palantir's market value to $188.1 billion. Meanwhile, Nvidia shares have run up 181.7% this year to lift its market capitalization to $3.4 trillion.