Seattle Seahawks coach Mike Macdonald faced an unusual conundrum this week as he game-planned for Sunday's rematch with the San Francisco 49ers. How much stock should he put into the film of the two teams' first meeting given how much both rosters have changed since Seattle's Thursday night loss at Lumen Field last month?

Left tackle Trent Williams’ ankle and wrist injuries could force him to miss his first 49ers game this season Sunday against the Seahawks.

San Francisco head coach Kyle Shanahan discussed Friday the 49ers' offensive line ahead of a matchup with the Seattle Seahawks, whose starting center abruptly retired this week.

The 49ers definitely will be without defensive tackle Kevin Givens (groin), punter Mitch Wishnowsky (back) and cornerback Charvarius Ward (personal), all of whom got an “out” designation Friday. Ward has not rejoined the team following the loss of his 1-year-old daughter last month.

Seattle Seahawks starting Connor Williams missed Wednesday’s and Thursday’s practice. His designation on the injury report is “personal reasons.” Members of the media are unaware of the reason behind his absence. Williams is entitled to a personal life and doesn’t owe us details.

The Seattle Seahawks have a rather significant shakeup along their offensive line. On Friday, head coach Mike Macdonald announced that starting center Connor Williams has decided to retire from the NFL.

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