Statins lower plasma cholesterol by upregulating LDL receptor gene expression and are consequently relatively ineffective in homozygous familial hypercholesterolemia (HoFH). The standard treatment ...

The most common is autosomal recessive, type 1, which is associated with HFEmutations, predominantly C282Y homozygous and rarely C282Y/H63D compound heterozygous. The highest prevalence of C282Y ...

As with humans, only a subset of these mice develop overt diabetes, and even heterozygous knockout mice are at increased risk of insulin resistance and glucose intolerance. Thus, the glucose ...

A genetic regulator of tomato sweetness has been identified through comparison of wild and domesticated varieties of the plant. Genetically engineering tomatoes to alter this gene increases sugar ...

The use of "anno domini" and "before Christ" to mark time began in the early days of Christianity, and they're still used to track calendar years today. When reading historical texts or delving ...

Introduction: The prevalence of heterozygous familial hypercholesterolemia (HeFH) is 1:250. Untreated individuals have up to a 20-fold increased risk for premature coronary artery disease (CAD). In ...

The term "alert and oriented" (AO) is a medical notation describing a person's level of consciousness and cognition (the ability to understand and learn through thought, experiences, and the senses).

When students become active doers of mathematics, the greatest gains of their mathematical thinking can be realized. The process of sense making begins when we create classrooms full of curious ...